Nitrosative Stress

What Is Nitrosative Stress, Also Called "Nitrostress"?

Nitrostress, or nitrosative stress, is the cause of multisystem diseases with deficiency and toxicity symptoms caused by aggressive nitric oxide radicals. The NO/ONOO stress syndrome has so far been almost completely ignored by conventional medicine. Physiologically, NO plays a causal role in several important reactions, such as defense against bacteria and the dilation of blood vessels. It acts as a neurotransmitter, controls functions in the mitochondria and itself also acts as a good radical scavenger. If there is too much NO in the body, its pathological, disease-causing effect comes to the fore.

– NO and Inflammation

Nitric oxide increases the body's readiness for inflammation and likewise increases the formation of histamine! Released inflammatory substances in turn increase the formation of NO – and the cycle continues toward stronger inflammation.

– Energy Blockade and Chronic Fatigue

Since nitric oxide can inhibit the enzymes of cellular respiration, the cell's own energy production is significantly reduced. The result is a disturbance of the magnesium-calcium balance in the cell. Amino acids and fats can no longer be properly utilized, and energy production declines. The respiratory chain of the mitochondria is blocked.

– How Is the Diagnosis Made?

In the laboratory diagnostics of NO stress, the following are determined: methylmalonic acid as a functional marker of an intracellular vitamin B12 deficiency, nitrotyrosine as a chemically modified amino acid or nitrophenylacetic acid as its breakdown product, and increased excretion of citrulline. People with cervical spine trauma, chronic fatigue, pain, headaches, concentration and memory problems, food allergies, unclear neurological diseases, elevated cholesterol and AD(H)D and much more.

Citrulline

Marker for NO formation (when formed in excess, a trigger of nitrosative stress) – from first morning urine

Nitrotyrosine

Nitrated by-product as a marker of long-term exposure to NO and thus nitrosative stress – from serum

Methylmalonic Acid

Determination of methylmalonic acid as an indicator of vitamin B12 deficiency – from first morning urine

Cause

Infections and inflammation can act as triggering factors for nitrosative stress through increased NO synthesis. But exposure to foreign substances (chemicals, heavy metals), medications (cytostatics, statins, nitrates, erectile dysfunction drugs, frequent courses of antibiotics, etc.), nicotine, private and/or work-related stress and heavy physical strain (competitive sports) can also cause increased NO synthesis. Other causes can be injuries to the cervical spine.

How Is It Treated?

With carefully and individually tailored high-dose micronutrients and methylcobalamin. In orthomolecular medicine, these micronutrients are described in connection with the function of the mitochondria.